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The Hidden Health Issues in Autism
Spectrum Disorders; Part 2

By Julie Priola

When my son was born he had Jaundice from high bilirubin levels, most common in premature babies, which my son was not, but it happens to 60% of all newborns (1). Bilirubin is a byproduct of the metabolism of red blood cells which takes place in the liver. He received blue Phototherapy and was deemed to be alright. I would remember this many years later.

MT Proteins
are responsible for:

1. Immune function

2. Neuronal development in the brain

3. Are heart protective

4. Protecting brain cells from oxidative stress

5. Involved in liver cell development and enzyme production

6. Bacteria regulation in the small intestine (GI tract)

7. The absorption of vitamins, minerals and other nutrients in the small intestine

8. The breakdown of certain dietary proteins (like wheat and dairy proteins)

9. Glucose metabolism

10. Antioxidant properties

11. Metal metabolism (flushing toxic metals and keeping needed metals in balance)

Having liver function tests done on our children is something that I consider to be very important because most people with ASD’s have compromised liver function. When something, anything, is going awry in the liver, other systems are affected and the liver is left far more vulnerable to toxicity by many substances; including meds….prescription and OTC. Before our appointment with his new doctor for absorption testing, I took my son to a traditional GP for liver function tests and found an enzyme that his liver is supposed to produce to regulate bilirubin levels was very low. Sometimes jaundice isn’t a symptom in compromised liver function, but we would find his liver had other problems too.

Two of the vast jobs of Metallothionein (MT) Proteins are liver cell development and enzyme production. The liver filters toxins from the blood and metabolizes old red blood cells, converts carbohydrates, as well as manufactures, stores and releases glucose as needed. In all, the liver performs some 500 function’s, it is a very valuable and hard-working organ. Jaundice occurs when the bilirubin count is too high, and when dramatically elevated, a condition called Kernicterus occurs which can cause brain damage (2). Most problems with the liver are very serious and can cause severe, permanent damage if not addressed; so my recommendation is for all people with ASD’s to get a comprehensive liver function test.

All of these issues got worse and worse until at age 20, living on his own, he found himself locked in a mental health ward on a court ordered commitment. His behaviors were exactly like a severe and persistent mental illness…..two of them actually. He was diagnosed with Schizophrenia and Bipolar Disorder. But in my heart I knew it wasn’t true. I had spent years studying and researching this and had finally found a doctor who would listen to me and prove that there was something internal causing all of these problems. So I got a lawyer, got my son out of that hospital and started getting the absorption testing he needed to find what was going on inside of him.(1) That is when I discovered all of the studies and research I had read were correct, there are serious hidden health issues in ASD’s that directly choreograph our children’s behaviors and exacerbate the issues in Autism.

The liver is directly involved in glucose metabolism also. We discovered my son’s symptoms of metal illness were from a malfunctioning glucose metabolism system that created a rollercoaster of reactive hypoglycemia. Thirty-six hours after having ALL sugars and high glycemic foods taken out of his diet he no longer had hypoglycemia and no longer displayed disordered thinking, no sleep disturbances, no mania or hyperactivity, no paranoia, no anger or rage, no repeating himself, his severe obsessions that controlled his life became normal interests, no extreme mood swings and he became a pleasure to be around. And for the first time in months, my husband and I were able to sleep a full 8 hours, rather than the usual two!

There are only two things which cause hypoglycemia; (3, 4)
1. Diabetic meds and/or insulin that are not properly regulated.
2. Sugars and other high glycemic foods in people with a glucose metabolism malfunction or other metabolic disorder, and improper enzyme production to process foods (this is called reactive hypoglycemia). *

Without one of those two things, there can be no hypoglycemia. People will often make the mistake of eating a high carbohydrate food like sugars or juices to alleviate hypoglycemia, but what that does is keep the hypoglycemia rollercoaster going and never ending.

Here is the cycle:

1. First, a sugar or high glycemic food is consumed.
2. Then the pancreas gets the signal that high amounts of sugars have entered the system and over-responds by dumping too much insulin.
3. This is when blood sugars plummet and hypoglycemia occurs.
4. The adrenals then emit cortisol and adrenalin/ephedrine to stimulate more glucose release from the liver (the fight or flight response).
5. But the liver is not functioning properly and does not respond.
6. The body is signaling that it needs more glucose and the person is in a “starving” mode, reaching for sugars and high glycemic foods to quickly raise blood sugars.
7. The pancreas again gets the signal that high amounts of sugar have entered the system and again over responds by dumping too much insulin.
8. Blood sugars once more plummet and hypoglycemia occurs again.
9. The adrenals release more cortisol and adrenalin/ephedrine in the “fight or flight” response.
10. The compromised liver does not respond to the signal from the adrenals to release more glucose…..and so on. (5)

This constant ride of high and low blood sugar and adrenal hormones can not only lead to symptoms of mental illness like mania, foggy thinking, anxiety, sleep disturbances and/or depression, but is also the leading cause of chronic fatigue. (5) Most often this shows itself in the morning by being unable to “get going”. It is exhausting when your body is constantly releasing these stress hormones over and over again throughout the day; it’s not unlike running a marathon each day! No wonder our kids can’t move in the morning. The removal of all sugars and high glycemic foods is necessary to stop the rollercoaster of hypoglycemia; therapies for adrenal fatigue are also recommended.

There are other food culprits out there that cause problems for our kids. Another function of MT Proteins is the breakdown of dietary proteins like wheat and dairy proteins. Most of us who are connected to ASD’s have heard about the Gluten Free/Casein Free diet and many families and individuals have had successes by removing these from their diets. One of the main benefits derived that I have heard from families is that their child seems “connected” again. That reconnection is understandable when you look at how these dietary proteins function in children with ASD’s.

Because of the intestinal dysbiosis in people with ASD’s, as discussed in January’s article, (www.asdrendrewolf.org/naturalremidies/healthwisemain.htm) “Hidden Health Issues in Autism Spectrum Disorders: Part 1” , many people with ASD’s are unable to break down some dietary proteins completely. This intestinal bacterium damages the lining of the intestines where nutrients are absorbed and does not manufacture the component that breaks down proteins. Then the intestine releases these incompletely digested proteins into the bloodstream. While most get flushed through the urine, many attach themselves to opiate receptors in the brain where they exert an opiate-like effect. The results are essentially like being drugged and similar to any drug can become highly addictive, so the person who is most sensitive to them also craves them the as a rule.
Some behaviors associated with Hypoglycemia are:

· Anxiety
· Mania
· Disordered or foggy thinking
· Sleep disturbances or insomnia
· Chronic fatigue
· Heart palpitations
· Hallucinations
· Depression
· Meltdowns in ASD’s

Wheat products provide the body with essential amino acids and B vitamins, nutrients that are commonly lacking in persons with ASD’s. If these nutrients are not fully digested then they cannot be absorbed and do all of the work needed to help metabolic systems run properly and they cannot be converted to make the hormones the body needs to function well. Implementing the GFCF diet is not easy, but many have found it to be invaluable in getting their children back again from the “drug” that held them hostage. To get you started or for more info and support, here is an excellent site and support community; www.gfcfdiet.com A Urinary Peptide Test is recommended to discover if a person has the GFCF sensitivity.

So in this article we see three more functions of the Metallothionein (MT) Proteins that have a direct impact on the malfunctions in Autism. The more one studies the disabled MT Proteins in Autism, the more we see how this astounding discovery by Dr. William Walsh and his colleagues at the Pfeiffer Treatment Center explains the broad spectrum of symptoms and mysteries in Autism Spectrum Disorders. For more info on these issues in Autism, visit www.hriptc.org/

* If you suspect hypoglycemia in your child, tests should be performed to rule out hormonal and enzyme deficiencies or other metabolic disorders. Disabled MT Proteins cannot perform their glucose metabolism functions in many people on the spectrum, a test for the copper/zinc imbalance in disabled MT Proteins is recommended for people with ASD’s.

And please visit the references provided for more information.

References:
1. www.kernicterus.org/
2.www.kernicterus.org/
3.www.hypoglycemia.org/hypo.asp
4. http://diabetes.niddk.nih.gov/dm/pubs/hypoglycemia/
5.www.drpodell.org/hypoglycemia_symptoms.shtml

 


Julie Priola is the Executive Director of the Autism Treatment and Resource Center in Duluth, Minnesota and the mother of a 21 year-old son with Asperger’s Syndrome who works, goes to college and lives independently.

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